I162 (ORF1a 3731) is one of the closest neighboring residues in the predicted tertiary structure. (b, c) T77 (ORF1a 3646) is in the middle of a conserved region spanning the predicted helical domain.
DeepMind Nsp6 structure (a) 106-108 deletion shortens predicted methionine rich loop, and recurrent 元7F mutation recognized early in the pandemic could also affect the loop’s conformation. Frequent mutations in Nsp6 in many significant variants.
Using rolling lineage or mutation counts from as of 27/June/2021.įigure 2. Ratio of the number of sequences of AY.2 or this sub-lineage (containing both ORF1a T3646A and I3731V mutations) and the total number of sequences containing Delta-defining S mutations in the USA. 3b and 3c show the positions of T77 (T3646) and I162 (I3731) relative to a methionine-rich loop.įigure 1. Fig 3a shows the positions in the 4/August/2020 DeepMind Nsp6 prediction of other mutations and Fig. 1), it contains two mutations in Nsp6 ( Fig 2) compared to one mutation in most recent B.1.617.2 sequences (T3646A) and a deletion in most VOCs (del3675/3677). Like AY.2, which is growing in the USA at a similar rate ( Fig. Since mid-May this sub-lineage is growing as a fraction of sequences in the USA and as a fraction of B.1.617.2 (including its sub-lineages). Potential significance: It is not clear that this sub-lineage is significant as it could be an artifact of growth of the number of infections where it is found for unrelated reasons and/or non-random sequencing and reporting. Combination of ORF1a:T3646A and ORF1a:I3731V. Most recent sequence: 23 June, 2021 ()Ĭountries circulating: USA (245 most in Missouri, Kansas and Mississippi), UK (1) as of 28/June/2021 ()ĭefined by: ORF1a:I3731V and common AY.1 mutations except for S:K417N. Earliest sequence: 23 April, 2021 Illinois, USA (searched for N:G215C, ORF1a:T3646A, ORF1a:I3731V on LANL analysis pipeline)
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